Comparative Effects of Purslane seed oil (PSO) and 5- Flourourasil on Ehrlich ascites carcinoma (EAC) in female albino mice

The present study was to evaluate anti-cancer effects of Purslane seed oil (PSO) (200g/kg. diet), 5-Flourourasil (20mg/kg b.w. i.p) and their combinatorial formulation in female mice induced by Ehrlich ascites cells for 21 consecutive days prior. Ten days after intraperitoneal inoculation of tumor EAC cells in mice, PSO was supplemented at (200g/kg. diet) daily for 21 consecutive days. On the 22th day, the mice were sacrificed for the estimation of tumor growth (tumor volume), and biochemical parameters (glucose, insulin, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), lipid peroxides (TBARS), protein thiols (Pr-SHs), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), total cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, 17β-estradiol and progesterone). The results of this study also showed that administration of Purslane seed oil (PSO), 5-Flourourasil both individually and in combination for 21 days to the carcinoma induced mice demonstrated a significant (P<0.01) decrease in tumor volume and a significant (P<0.01) improvement in biochemical parameters and life span as compared to the EAC control mice than either agent alone. On the other hand, the results clearly suggest that the combination of PSO and 5-Flourourasil produced higher antioxidant activities on experimental EAC control as well as 5-Flourourasil mice than their individual influences.